东华大学学报(英文版)

2019, v.36(05) 437-444

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

Folic Acid-Polyethyleneimine-Ethosome as a Potential Tumor Targeting Carrier: Preparation, Characterization and in vitro Evaluation
Folic Acid-Polyethyleneimine-Ethosome as a Potential Tumor Targeting Carrier: Preparation, Characterization and in vitro Evaluation

宋新然;马琳琳;GOMAA Elfawal;洪火炎;梁经天;孙美琪;张林;王红声;

摘要(Abstract):

A novel composite carrier of folic acid( FA)-polyethyleneimine( PEI)-ethosome( Eth)( FA-PEI-Eth)was developed for the treatment of cancers through loading and targeting delivery of multidrug( including gene and other drugs) into cancer cells. Physical and chemical property tests were done to prove the grafting of the composite. Gel retardation test was done to determine the optimal ratio of DNA@ PEI complex,and cytocompatibility tests and tumor cell uptake tests were done to evaluate the efficiency of the composite. The results demonstrated that the FA-PEI-Eth could effectively deliver a gene and other drugs into tumor cells simultaneously,and suggested that this composite would be a promising carrier in tumortargeted therapy applications.

关键词(KeyWords):

Abstract:

Keywords:

基金项目(Foundation): Shanghai Science and Technology Committee Project,China(No.18490740400);; Open Foundation of Key Laboratory of Science&Technology of Eco-Textile,China(No.Eco-KF-201612);; Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University,Zhejiang Chinese Medical University,China(No.ZYAOX2018035);; Project of Health and Family Planning Commission of Zhejiang Province,China(No.2018KY831)

作者(Author): 宋新然;马琳琳;GOMAA Elfawal;洪火炎;梁经天;孙美琪;张林;王红声;

Email:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享